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Tetracycline Hydrochloride is generally more effective for aerobic bacteria (which Columnaris is only aerobic however Aeromonas and many other pathogens can be anaerobic).
It should also be noted as to Columnaris that although it is aerobic, it is also gram negative, whereas Tetracycline Hydrochloride is less effective for gram negative bacterium.
This would not only include and in-tank treatment but use as part of a "Fish Bath" treatment too.
Further information: Fish baths, Dips, Swabs An old standby that is still useful and can be used in combination with Malachite Green (especially effective in combination with MG at strength when treating Ich in scale less fish) or Acriflavin (do not combine with copper sulfate).
It interferes with the production of proteins that the bacteria need to multiply and divide (bacteriostatic).
However many bacterial pathogens have developed resistance to Tetracycline Hydrochloride.
For aquatic use Sulfa are often maligned by many aquarists as not effective or out of date, yet in reality Triple Sulfa often will work where other antibiotics fail and sometimes with less side effects as well (this is not to say Sulfas do not have side effects as they are somewhat toxic, producing blood abnormalities and kidney damage when indiscriminately used).Trimethoprim is found in (Recommended place to purchase to support this free information): *AAP Maracyn Plus- contains Sulfamethazine and Trimethoprim (manufactured by Fritz/Mardel) Reference: Combined Activity of Sulfamethoxazole, Trimethoprim, USE: Tetracycline is the name of a large class of antibiotics produced by Streptomyces bacteria.These include Tetracycline Hydrochloride (to be discussed here) and several others which, although closely related, often yield very different results (although side effects may be very similar).However Trimethoprim has no proven effectiveness for anaerobic infections, so if the causes of an Aeromonas is anaerobic (which most are), then this or antibiotics containing Trimethoprim would be a poor choice.USE: A good alternative to 100% sulfas, although a more harsh antibiotic toward nitrifying bacteria. Contraindications *Can be very harsh to nitrifying bacteria in an aquarium, do not over dose and use only in well established aquariums.